Effect of starting material particle size on its agglomeration behavior in high shear wet granulation

effect of sub-grid scales on large eddy simulation of particle deposition in a turbulent channel flow

چکیده ندارد.

Effect of temperature on wet agglomeration of crystals

Objective(s):This study dealt with the wet agglomeration process in which a small quantity of binder liquid was added into a suspension of crystals, directly in the stirring vessel where the crystallization took place. The purpose of this investigation was evaluation of the effect of temperature on the agglomeration process in order to gain insight into the mechanism of the formation of the agg...

Effect of operating conditions and physico–chemical properties on the wet granulation kinetics in high shear mixer

A PAT approach to improve process understanding of high shear wet granulation through in-line particle measurement using FBRM C35.

This article summarizes the investigation of in-line particle characterization during high shear wet granulation (HSWG) using focused beam reflectance measurement (FBRM) for enhanced process understanding, which is part of an effort to develop this drug product within the framework of quality by design (QbD) and process analytical technology (PAT). Traditionally, the effectiveness of in-line mo...

Scale-up studies on high shear wet granulation process from mini-scale to commercial scale.

A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...